医用生物材料——聚乙丙交酯PGLA(90/10)的研究Study on Medical Biomaterials of Poly (glycolide-lactide)
徐纪刚,陈功林
XU Ji-gang; CHEN Gong-lin (China Textile Academy;
摘要(Abstract)：
利用搅拌反应釜合成了乙交酯和L-丙交酯的共聚物PGLA(90/10),并用自制的纺丝机对聚合物进行纺丝,得到PGLA(90/10)纤维。研究了聚合过程中特性黏度、单体转化率等的变化规律,应用IR、1H-NMR、DSC、TG、毛细管流变仪等对聚合物的结构、热性能、流变性能进行了表征。
Poly(glycolide-lactide) was synthesized by copolymerization of glycolide (GA) and L-lactide (LA) (GA/LA=90/10 in mol) in the stirred-tank reactor, then PGLA(90/10) fibers were obtained by melt spinning. The influences of polymerization time on the polymerization were studied in detail. The structure and properties of PGLA(90/10) were analyzed by IR, 1H-NMR, DSC, TGA, capillary rheogeniometer.
关键词(KeyWords)：
聚乙交酯;聚丙交酯;生物降解
polyglycolide, polylactide, biodegradation
基金项目(Foundation):
作者(Authors):
徐纪刚,陈功林
XU Ji-gang; CHEN Gong-lin (China Textile Academy;
参考文献(References)：
- [1]D K Gilding,A M Reed.Biodegradable polymers for use in surgery-polyglycolic/polyl(actic acid)homo-and copolymers:1.Polymer,1979,20:1459￣1464.
- [2]赵耀明,黄俊豪等.生物降解医用材料-聚乙丙交酯的研究.合成纤维工业,1997,20(4):1￣4.
- [3]杨飞,杨亚明,刘建红等.聚乙交酯公斤级生产途径探索.北京理工大学学报.2001,21(4):518￣523.
- [4]宋谋道,余艺华等.乳酸、羟基乙酸均聚物及共聚物的合成与结构表征.离子交换与吸附,1995,11(3):245￣252.
- [5]David Wasserman,Charles Curtis Versfelt.Use of stannous octoate catalyst in the manufacture of Llactide-glycolide copolymer sutures.1974,USP:3839297.
- [6]Sastry,Bommakanti Bala Subrahmanya,et al.Method for the production of polyglycolic acid.2000,USP:6150497.