张幼珠,尹桂波,吴佳林,常丽娜
ZHANG You-zhu , YIN Gui-bo, WU Jia-lin, CHANG Li-na (College of Material Engineering of Suzhou University

• 1:苏州大学材料工程学院
• 2:苏州大学材料工程学院
• 3:苏州大学材料工程学院
• 4:苏州大学材料工程学院 江苏苏州215021

摘要(Abstract)：

以98%的甲酸为溶剂,不同质量分数的再生丝素溶液和3.5%的壳聚糖溶液以质量比70∶30共混静电纺丝。测定了壳聚糖的含量对共混膜的结构及力学、溶解等性能的影响。结果表明:随着壳聚糖相对含量的增加,丝素β化程度提高,纤维结晶度增大,丝素与壳聚糖以70∶30共混时的溶失率最小;甲醇处理后,溶失率明显降低;共混纳米纤维的断裂强度随着壳聚糖相对含量的增大而增加,柔软性也逐渐提高;共混纤维膜具有优异的抗菌性。
The electrospinning of various concentrated regenerated silk fibroin(SF) solution and 3.5 % chitosan(CS) solution with the composition ratio 70∶30 was performed using 98 % formic acid as spinning solvent. The influence of chitosan's relative content on blended membrane's microstructure, mechanical property and the rate of water-dissolved was measured. The result indicated that with the relative content of chitosan increased, the β-sheet and crystallinity of SF were enhanced. When the composition ratio was 70∶30, the rate of water-dissolved was least. After 60 min treatment by methanol, the rate of water-dissolved decreased significantly. The breaking strength and pliability of blended membrane were increased gradually with the increased content of chitosan. The electrospun SF/CS membrane had excellent antibacterial property.

关键词(KeyWords)： 再生丝素;壳聚糖;静电纺丝;微细结构;力学性能;抗菌性
regenerated silk fibroin, chitosan, electrospinning, microstructure, mechanical property, antibacterial property

Abstract:

Keywords:

基金项目(Foundation): 江苏省高校重点实验室开放研究项目(S81150033)。

作者(Author): 张幼珠,尹桂波,吴佳林,常丽娜
ZHANG You-zhu , YIN Gui-bo, WU Jia-lin, CHANG Li-na (College of Material Engineering of Suzhou University

参考文献(References)：

• [1]阳元娥,罗发兴.壳聚糖及其衍生物在医药中的应用[J].中国医药工业杂志,2002,33(8):408-411.
• [2]常丽娜,张幼珠,张晓东.静电纺丝工艺参数对丝素/壳聚糖纳米纤维的形貌及直径的影响[J].合成纤维,2006,35(2):14-17.
• [3]常丽娜,张幼珠.静电纺丝素/壳聚糖纳米纤维的研究[J].丝绸,2005,12:28-30.
• [4]P R Carey,P Fast H kaplan,et a1.Molecular structure of the protein crystal from Bacillus thuringiensis-a Raman spectroscopic studybiochimica et[J].Biophsic Acta,1986,872:169-176.
• [5]E Li-Chan,S Nakai,M Hirotsuksako.Raman spectroscopy as a probe of protein structure ruction relationships in foods[M].Edited by R Y Yada,R L Jackman and J L Smith.chapman&Hall,1994.163-197.
• [6]Z Shao,F Vollrath,et al.Analysis of spider silk in native and supercontracted states using Raman spectroscopy[J].Polymer,1999,40:2493-2500.
• [7]J Magoshi,Y Magoshi.Physical properties and structure of silk[J].J Poly Sci Poly Phy Ed,1977,15:1675-1683.