合成纤维

2008, No.236(10) 18-20+26

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湿法共混纺丝载药纤维中药物含量的测定
Determination of Drug Contents in Wet-spinning Medicated Fibers

申夏夏;余灯广;郑妍;马宗会;朱利民;
SHEN Xia-xia,YU Deng-guang,ZHEN Yan,MA Zong-hui,ZHU Li-min(College of Chemistry,Chemical Engineering and Biotechnology,Donghua University,Shanghai 201620,China)

摘要(Abstract):

建立了湿法纺丝制备载药纤维中布洛芬含量的反相高效液相色谱检测方法。色谱柱为Kromasil 100A C18(250 mm×4.6 mm,5μm),流动相为甲醇-水-冰醋酸(体积比80∶19∶1)混合溶液,流速为0.8 mL/min,进样量为5μL,检测波长为264 nm,柱温为室温。结果表明:布洛芬在5~200μg/mL范围内时,色谱峰面积与质量浓度之间线性关系良好,相关系数0.9993。该方法简单、快捷、准确可行。
A method for the determination of Ibuprofen in wet-spinning drug-loaded fibers by reversed-phase high performance liquid chromatography was developed and validated.The chromatographic column of Kromasil 100 A C18(250 mm×4.6 mm,5 μm) was employed in the analysis.Solution containing methanol,water and acetate acid in the proportion of 80∶19∶1 in volume was used as the mobile phase,passing through the column at a flow-rate of 0.8 mL/min.Volume of the volumetric loop used was 5 μL.The column was run at room temperature and the detection wavelength was 264 nm.Linear relationship between the absorbance area and concentration of Ibuprofen was obtained over the range of 5~200 μg/mL with a correction coefficient value of 0.999 3.The method was simple,rapid,sensitive,accurate and feasible.

关键词(KeyWords): 载药纤维;反相高效液相色谱;湿法纺丝;布洛芬;共混
drug-loaded fiber,RP-HPLC,wet spinning,Ibuprofen,blending

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基金项目(Foundation): 教育部生物医用纺织材料“111项目”(项目编号B07024);; 长江学者和创新团队发展计划(IRT0526);; 中英药用纺织品联合实验室提供资助

作者(Author): 申夏夏;余灯广;郑妍;马宗会;朱利民;
SHEN Xia-xia,YU Deng-guang,ZHEN Yan,MA Zong-hui,ZHU Li-min(College of Chemistry,Chemical Engineering and Biotechnology,Donghua University,Shanghai 201620,China)

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