徐倩;齐鲁;
XU Qian, QI Lu (The Key Lab of Functional and Modified Fiber, Research Institute of Biologic and Spinning Materials,Tianjin Polytechnic University, Tianjin 300160)

• 1:天津工业大学生物与纺织材料研究所改性与功能纤维重点实验室
• 2:天津工业大学生物与纺织材料研究所改性与功能纤维重点实验室 天津300160
• 3:天津300160

摘要(Abstract)：

目前医用可吸收手术缝合线广泛应用于医学的外科手术中,是生物医用高分子研究中最活跃的研究领域之一。对几种天然及人工合成可吸收手术缝合线及其在体内的吸收情况、降解性能的研究状况及进展进行综述,指出我国大力开发生物可降解医用纤维研究工作的重要意义。
Absorbable suture had been widely used in surgical operation which was one of the most active domains in biomedicine macromolecule research. This paper made a general review about absorbability, degradation and research status of the biomaterial. It also pointed out the importance of researching and developing biodegradable medical fibers in China.

关键词(KeyWords)： 手术缝合线;生物降解;生物材料;医用纤维
surgical suture, biological degradation, biomaterial, medical fibers

Abstract:

Keywords:

基金项目(Foundation):

作者(Authors): 徐倩;齐鲁;
XU Qian, QI Lu (The Key Lab of Functional and Modified Fiber, Research Institute of Biologic and Spinning Materials,Tianjin Polytechnic University, Tianjin 300160)

参考文献(References)：

• [1]吴询,赵耀明.生物降解医用纤维的研究进展[J].广东化纤,1996,12(4):31-34.
• [2]艾莉,杨青芳,邰红勤.生物可降解医用纤维[J].北京纺织,2004,25(6):26-29.
• [3]Singh D K,Ray A R.Biomedical applications of chitin,chitosan,and their derivatives[J].JMS-Rev Macro-mol Chem Phys,2000,40(1):71-77.
• [4]Goosen,Mattbeus F A.Application of chitin and chitosan[M].Cancaster PA:Technomic Pub,1997.407-409.
• [5]苏秀榕,李太武,曾名勇.用壳聚糖制备可吸收性手术缝合线的研究[J].辽宁师范大学学报,1996,19(4):321-324.
• [6]Nishiyama M,Kobayashi Y,et al.Paper-marking process with regen-erate chitin fibers[P].US,4392916.1983-07-12.
• [7]郭振友,温永堂,傅振刚等.医用可吸收生物材料缝合线的研究[J].中国纺织大学学报,1999,25(2):89-93.
• [8]knaul J,Hooper M,Chanyi C,et al.Improvements in the drying process for wet-spun chitosan fiber[J].Journal of Applied Polymer Science,1988,69(7):1435-1444.
• [9]De Lucca,George V,KezarⅢ,et al.High strength fibers from chitin derivatives[P].US,5021207.1991.
• [10]秦冬雨,王文祖,医用缝合线的结构与性能[J].产业用纺织品,2001,19(10):16-19.
• [11]郑淑芬,王素珍,辛银花等.生物降解纤维在临床缝合线中的应用[J].生物学杂志,2001,18(1):34-35.
• [12]温永堂,王东光,付振刚等.胶原医用可吸收缝合线的研制[J].天津纺织工学院学报,1992,11(3):1-8.
• [13]李培仁.胶原手术缝线[J].明胶科学与技术,2001,(6):79-82.
• [14]范尧明.医用缝合线的研究进展[J].纺织导报,2006,(1):58-61.
• [15]辛银花.医疗缝合线用生物降解纤维[J].纺织科技进展,2005,(3):l2-13.
• [16]何理平,李文平,罗国良等.可吸收手术缝合线的研究进展[J].创伤外科杂志,2005,(8):4-6.
• [17]杜春麓.医用功能纤维[J].现代纺织技术,2000,8(3):58-62.
• [18]汪忠稿,费立民.可吸收合成线-聚羟基乙酸线[J].中华外科杂志,1984,22(6):377-380.
• [19]S A Gordeyev,YU P Nekrasov,S J Shilton.Biodegradable fibrs of poly(3-hydroxybutyrate)produced by high speed melt spinning and spin drawing[J].J Appl Polym Sci,2001,81:2260-2264.
• [20]Pearce EM.Contemporary Topic in Polymer Science,1997,2:251.
• [213]李良,李国明.聚乳酸的合成现状及在生物医学领域中的应用[J].安徽化工,2001,17(6):15-18.
• [22]史铁钧,董智贤.聚乳酸的性能、合成方法及应用[J].化工新型材料,2001,29(5):13-16.
• [23]崔红星等.聚乳酸类可吸收手术缝合线的研究进展[J].合成纤维2004,(4):15-17.
• [24]Takahashi K,Tanigguchi I,Miyamoto M,et al.Melt/solid polyconden-sation of glycolic acid to obtain high-molecular-weight poly(glycolic acid)[J].Polymer,2000,41(24):8725-8728.
• [25]Tolga M A,Erkan O,Abdullah S,et al.Effect of human pancreatic juice and bile on the tensile strength of suture materials[J].The American Journal of Surgery,2004,188(2):200-203.
• [26]郭敏杰,刘振.聚对二氧环乙酮-乙交酯缝合线体外降解研究[J].高分子学报,2002,5(2):157-162.
• [27]郭敏杰,刘俊.生物吸收性合成聚酯纤维晶体模型的描绘[J].天津轻工业学院学报,2003,18(3):31-33.
• [28]Mochizuki M,Hayashi T,Nakayama K,et al.Studies on biodegradable poly(hexano-6-lactone)fibers.Part2:Environmental degradation[J].Pure and Applied Chemistry,1999,71(11):2177-2188.
• [29]Baimark Y,Molloy N,et al.Synthesis,characterization and melt spin-ning of a block copolymer of L-lactide andβ-caprolactone for potential use as an absorbable monofilament surgical suture[J].Journal of Materials in Medicine,2005,16(8):699-707
• [30]Tomihata K,Suzuki M,Tomita N.Handling characteristics of poly(L-lactide-co-ε-caprolactone)monofilament suture[J].Bio-Medical Material and Engineering,2001,15(5):381-391.
• [31]Tomihata K,Suzuki M,Ikada Y.The pH dependence of monofilament sutures on hydrolytic degradation[J].Journal of Biomedical Materials Research,2001,58(5):511-518.
• [32]Uddin A J,Katayama N,Ohkoshi Y,et al.Controlling the mechanical properties of poly(L-lactide-ε-caprolactone)monofilament sutures by an acetone/water treatment[J].Journal of Polymer Science,Part B:Polymer Physics,2002,40(21):2449-2462.
• [33]季益萍.医用缝合线研究动态[J].产业用纺织品,2004,22(12):34-37.
• [34]吕悦慈.医用缝合线的应用和发展[J].上海纺织科技,2005,33(7):31-33.
• [35]刘青.国外医用缝合线的发展状况[J].国外医学生物学过程分册,1993,16(6):324-328.