王立新,张幼珠,李双燕,尹桂波
WANG Li-xin,ZHANG You-zhu,LI Shuang-yan,YIN Gui-bo(College of Textile and Clothing Engineering of Suzhou University

• 1:苏州大学纺织与服装工程学院

摘要(Abstract)：

采用静电纺丝制备了聚乳酸-乙醇酸(PLGA)纤维膜,通过失重率、相对分子质量变化、断裂强度测试、SEM、DTA和X-射线衍射等方法详细研究了静电纺PLGA纤维膜的降解性能。结果证明:PLGA纤维膜可在磷酸酯(PBS)溶液中降解,降解前两周相对分子质量和断裂强度快速下降,失重率快速提高;降解4w时纤维发生断裂;10w时纤维大部分断裂崩解成小碎粒;降解前后静电纺PLGA纤维膜始终为无定形聚合物。
PLGA(polylactide-co-glycolide,75/25) fiber membranes were prepared by electrospinning.The degradation of PLGA fiber membranes were characterized by weight loss,molecular weight,breaking intensity,SEM,DTA and X-ray.The research proved that PLGA fiber membranes were degradable in phosphate-buffered solution.During the first two weeks,molecular weight and breaking intensity decreased quickly and weight loss increased rapidly.SEM observation found the fibers broke at 4th week,furthermore,the fibers mostly broke into pieces at 10th week.According to DTA and X-ray analysis,PLGA should be amorphous structure both before and after degradation.

关键词(KeyWords)： PLGA;静电纺丝;体外降解
polylactide-co-glycolide,electrospin,in vitro degradation

Abstract:

Keywords:

基金项目(Foundation): 江苏省高校重点实验室开放研究课题(KJS0817)

作者(Author): 王立新,张幼珠,李双燕,尹桂波
WANG Li-xin,ZHANG You-zhu,LI Shuang-yan,YIN Gui-bo(College of Textile and Clothing Engineering of Suzhou University

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