丝素-聚己内酯纳米纤维膜的制备工艺Preparation of Nanofiber Membranes of Silk Fibroin-Polycaprolactone
尹云雷,普丹丹,熊杰
YIN Yun-lei,PU Dan-dan,XIONG Jie
摘要(Abstract)：
以六氟异丙醇(HFIP)为溶剂,采用静电纺丝技术制备丝素(SF)-聚己内酯(PCL)复合纳米纤维膜。采用热场发射扫描电镜、Image-Pro Plus图像分析和力学拉伸的方法表征了纳米纤维膜的结构与力学性能。通过设计的三因素四水平正交试验对复合纳米纤维膜的多个指标进行了分析,采取归一化数据处理及平均权重分配的方式量化了复合纳米纤维膜的品质,确定了共混复合纳米纤维膜制备的最优工艺参数,并且采用最佳工艺参数制备了SF-PCL复合纳米纤维膜,分析了其力学性能。结果表明:在溶质质量分数为6%、溶质SF与PCL质量比为3∶2、纺丝流速1.2 mL/h时,SF-PCL复合纳米纤维膜具有较好的品质;双轴拉伸时的破坏机制与单轴不同,其断裂应力和应变只是单轴时的一半左右,膜的力学性能表现为各向同性。
Taking six fluorine isopropyl alcohol(HFIP) as solvent and adopting electrospinning technique to prepare silk fibroin(SF)-polycaprolactone(PCL) composite nanofiber membranes. By thermal field emission scanning electron microscopy, Image- Pro Plus image analysis and mechanical stretching methods to characterize the structure and mechanical properties of nanofiber membranes. Multi-index of the composite nanofiber membranes were analyzed by orthogonal experiment of three factors and four levels, adopting normalized data processing and average weight allocation of quantifying the quality of composite nanofiber membranes, the optimal technological parameters of composite nanofiber membranes preparation were determined. In addition, the SF- PCL composite nanofiber membranes were prepared by the optimum process parameters, and its mechanical properties were analyzed. The results showed that SF- PCL composite nanofiber membranes were with better quality when the solute concentration was 6%, m(SF)∶m(PCL) was 3∶2 and the spinning flow rate was 1.2 m L/h. The fracture mechanism of biaxial stretching was different from that of uniaxial, the stress and strain were only about half that of uniaxial. The mechanical properties of the membrane were isotropic.
关键词(KeyWords)：
静电纺丝;丝素蛋白;聚己内酯;正交试验;力学性能
electrospinning;silk fibroin;polycaprolactone;orthogonal test;mechanical property
基金项目(Foundation): 国家自然科学基金项目(11272289)
作者(Author):
尹云雷,普丹丹,熊杰
YIN Yun-lei,PU Dan-dan,XIONG Jie
DOI: 10.16090/j.cnki.hcxw.2017.02.014
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