张锴,俞昊,周哲,朱美芳,陈彦模
ZHANG Kai,YU Hao,ZHOU Zhe,ZHU Mei-fang,CHEN Yan-mo(State Key laboratory for Modification of Chemical Fibers and Polymer Materials

• 1:东华大学纤维材料改性国家重点实验室
• 2:东华大学纤维材料改性国家重点实验室
• 3:东华大学纤维材料改性国家重点实验室
• 4:东华大学纤维材料改性国家重点实验室

摘要(Abstract)：

对β-羟基丁酸酯-co-β-羟基戊酸酯(PHBV)/二氯甲烷(CH2Cl2)溶液进行静电纺丝制备PH-BV纳米纤维毡。采用正交设计实验的方法,对溶液浓度、电压、有机盐(苄基三乙基氯化铵)含量、溶液供给速率、喷丝孔孔径5种因素与纤维直径和直径的多分散性之间的关系进行了研究。通过优化,制备出了平均直径为80nm的纤维。
PHBV nano fiber mats were electrospun form β-hydroxybutyrate-co-β-hydroxyvalerate(PHBV)/dichloromethane solution.The influences of solution concentration,potential,organic salt content(benzyl triethylammonium chloride),solution feeding rate,and diameter of capillary on the diameter of the fibers and its distribution were studied.By optimized conditions,the average diameter of electrospun fibers reached 80 nm.

关键词(KeyWords)： 羟基丁酸和羟基戊酸共聚物;静电纺丝;直径;多分散性;正交设计
PHBV,electrospinning,diameter,distribution,orthogonal testing analytical method

Abstract:

Keywords:

基金项目(Foundation): 上海市纳米专项(0452nm006)资助;; 上海市重点基础研究项目(06JC14003)资助

作者(Author): 张锴,俞昊,周哲,朱美芳,陈彦模
ZHANG Kai,YU Hao,ZHOU Zhe,ZHU Mei-fang,CHEN Yan-mo(State Key laboratory for Modification of Chemical Fibers and Polymer Materials

参考文献(References)：

• [1]Wan Ju Li,Cato T Laurencin,et al.Electrospun nanofibrous structure:A novel scaffold for tissue engineering[J].J Biomed Mater Res,2002,60:613-621.
• [2]Xinhua Zong,Harold Bien,et al.Electrospun fine-textured scaffolds for heart tissue constructs[J].Biomaterials,2005,26:5330-5338.
• [3]Hiroyuki Inoguchi,Keun Kwona,et al.Mechanical responses of a compliant electrospun poly(L-lactide-co-e-caprolactone)small-diameter vascular graft[J].Biomaterials,2006,27:1470-1478.
• [4]Dhirendra S Katti,Kyle W Robinson,et al.Bioresorbable nanofiber-based systems for wound healing and drug delivery:optimization of fabrication parameters[J].J Biomed Mater Res Part B:Appl Biomater,2004,70B:286-296.
• [5]叶鹤荣,胡平等.PHBV/HA骨修复材料的研究[J].功能高分子学报,2004,17(9):499-502.
• [6]费强,尚龙安等.生物可降解材料PHBV的细胞毒性评价的研究[J].安全与环境学报,2005,5(6):47-51.
• [7]Seong Ok Han,Won Keun Son,Dongwhan Cho.Preparation of porous ultra-fine fibres via selective thermal degradation of electrospun polyetherimide/poly(3-hydroxybutyrate-co-3-hydroxyvalerate)fibres[J].Polymer Degradation and Stability,2004,86:257-262.
• [8]Jae Shin Choi,Sung Won Lee,et al.Effect of organosoluble salts on the nanofibrous structure of electrospun poly(3-hydroxybutyrate-co-3-hydroxyvalerate)[J].International Journal of Biological Macromolecules2004,34:249-256.
• [9]方壮熙,张璐,韩涛,胡平.PHBV电纺纤维结构与形态的研究[J].高分子学报,2004,(8):500-505.
• [10]庄楚强,吴亚森.应用数理统计基础(第二版)[M].华南理工大学出版社,2004.383-574.
• [11]Deitzel J M,Kleinmeyer J,et al.The effect of processing variables on the morphology of electrospun nanofibers and textiles[J].Polymer,2001,42:261.
• [12]Weiwei Zuo,Meifang Zhu,et al.Experimental study on relationship between jet instability and formation of beaded fibers duringelectrospinning[J].Polymer Engineering and Science,2005,45:704-709.
• [13]Hohman MM,Shin M,Rutledge G,et al.Electrospinning and electrically forced jets.I.Stability theory[J].Physics of Fluids,2001,13(8):2201-2220.
• [14]Hohman M M,Shin M,Rutledge G,et al.Electrospinning and electrically forced jets.II.Applications[J].Physics of Fluids,2001,13(8):2221-2236.
• [15]Thandavamoorthy Subbiah,G S Bhat,et al.Electrospinning of Nanofibers[J].Journal of Applied Polymer Science,2005,96:557-569.