何莉,王立新,张幼珠
HE Li,WANG Li-xin,ZHANG You-zhu(College of Material Engineering

• 1:苏州大学材料工程学院
• 2:苏州大学材料工程学院
• 3:苏州大学材料工程学院 江苏苏州215021
• 4:江苏苏州215021

摘要(Abstract)：

将药物——消炎痛和聚乳酸(PLA)同时溶解在三氯甲烷∶丙酮(体积比2∶1)的混合溶液中,制得均匀的纺丝液,通过静电纺丝制备载药PLA纤维膜。通过扫描电镜(SEM)观察其形貌结构;通过紫外分光光度计检测其释放在磷酸缓冲溶液(PBS)中药物的吸光度,并计算其释药速率。结果表明:纤维的平均直径随着含药量的增加而减小,随着PLA质量分数的增加而增加;释药速率随着纤维直径的减小而加快;与纯药粉的释药速率相比,载药PLA纤维膜有明显的缓释性,提高了药物的利用率及安全性。
Polylactide(PLA)and indomethacin were dissolved in a mixxed solvent of chloroform and acetone(2/1 v/v)to make even spinning solution.Then drug carrier PLA microfibers were prepared by electrospining.The microfibers' morphology was observed by SEM.The absorbency of the drug in PBS was detected and the velocity of drug release was counted by UV-visible spectroscopy.The results showed the average diameter of microfibers was decreased when the concentration of drug increased,and the diameter was increased with the concentration of PLA increased.The velocity of drug release was increased when the diameter of the fiber reduced.Compared with drugs,PLA microfibers had obviously smooth release of drug and improved therapeutic efficacy and safety of drugs.

关键词(KeyWords)： PLA;消炎痛;静电纺丝;药物释放
PLA,indomethacin,electrospinning,drug release

Abstract:

Keywords:

基金项目(Foundation): 江苏省高校重点实验室开放研究课题(编号S8115033)

作者(Author): 何莉,王立新,张幼珠
HE Li,WANG Li-xin,ZHANG You-zhu(College of Material Engineering

参考文献(References)：

• [1]刘袖洞,马小军,袁权.药物释放系统[J].化工学报,2005,56(6):955-960.
• [2]Jing Zeng,Lixin Yang,et al.Infuence of the drug compatibility with polymer solution on the release kinetics of electrospun fiber formulation[J].Controlled Release,2005,105:43-51.
• [3]Kenawy E R,Bowlin G I,et al.Release of tetracycline hydrochloride from electrospun poly(lacticacid)and a blend.[J].Control Release,2002,81:57-64.
• [4]Kim kwangsok,Luu Yen K,et al.Incorporation and controlled release of a hydrophilic antibiotic using poly(lactide-co-glycolide)-based electrospun nanofibrous scaffolds[J].Journal of Controlled Release,2004,98(1.):47-56.
• [5]杨千帆.聚乳酸(PLA)在药物控释体系中的应用及其前景[J].中国西部科技,2003,(6):18-19.
• [6]顾书英,任杰,诸静.聚乳酸的静电纺丝行为及其纤维结构研究[J].材料导报,2005,(1.9):383-385.
• [7]任杰,董博.聚乳酸纤维制备的研究进展[J].材料导报,2006,(2):82-85.
• [8]姚军燕,杨青芳,周应学等.高性能聚乳酸纤维的研究进展[J].化工进展,2006,(3):286-291.
• [9]赵敏丽,隋刚,邓旭亮等.静电纺丝法纺制聚乳酸纳米纤维无纺毡[J].合成纤维工业,2006,(29):5-7.