郭红霞,王笑星,刘淑强,吴改红,郭浩鹏,苏浩
GUO Hong-xia,WANG Xiao-xing,LIU Shu-qiang,WU Gai-hong,GUO Hao-peng,SU Hao

• 1:太原理工大学轻纺工程学院

摘要(Abstract)：

研究了单股型聚乳酸医用缝合线的制备及对其进行载药微球附载效果测试与方案优化。采用正交试验法,设计了3个因素:溶液浓度、震荡时间、浸轧次数,每个因素设定5个水平。按照试验方案对聚乳酸缝合线进行微球附载后,测试其附载后质量增加率。结果表明:当溶液质量浓度为6 g/m L、震荡时间为10 min、浸轧次数为4次时,所制备的聚乳酸医用缝合线载药微球附载增重率最大,即附载效果最好。
The preparation of the single PLA medical suture and the test and scheme optimization of PLAmicrospheres to load solution of PLA medical suture are researched.The orthogonal test method is used,and three factors are designed,including solution concentration,shock time and number of pad,each fac-tors set five levels.The PLA filaments are loaded microspheres according to the test plan.The weight gainrate after loaded is tested.The result shows that the weight gain rate of the microspheres load on the PLAmedical suture is largest when the concentration of solution is the 6 g/m L,the shock time is 10 min,numberof pad is 4 times.

关键词(KeyWords)： 聚乳酸长丝;医用缝合线;微球附载
polylactic acid filament;surgical suture;microspheres load

Abstract:

Keywords:

基金项目(Foundation): 山西省大学生创新实验项目(2013067);; 太原理工大学校基金项目(2012L074);太原理工大学校青年科学基金项目(2013T020、2013T021、2013T022)

作者(Author): 郭红霞,王笑星,刘淑强,吴改红,郭浩鹏,苏浩
GUO Hong-xia,WANG Xiao-xing,LIU Shu-qiang,WU Gai-hong,GUO Hao-peng,SU Hao

DOI: 10.16090/j.cnki.hcxw.2015.12.008

参考文献(References)：

• [1]刘青.国外医用缝合线发展状况[J].国外医学生物医学分册,1993,16(6):324-328.
• [2]李孝红,袁明龙,熊成东,等.聚乳酸及共聚物的合成和在生物医学上的应用[J].高分子通报,1999(1):24-32.
• [3]尚茂林,吴景梅,郭春燕.聚乳酸载药微球的制备及修饰研究进展[J].中国药师,2013,16(8):1 242-1 245.
• [4]曹婷颖,顾月清,高向东.聚乳酸载药微球的制备和给药方法[J].药学进展,2006,30(10):448-452.